(2022) Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study. Bmc Complementary Medicine and Therapies.
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Abstract
Background: Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and efectiveness. Methods: This study aimed to explore the anti-infammatory efect (paw edema test) and the anti-nociceptive efect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28±6nm and 12±3nm were frst prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelifed. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of infammation or pain in acute and chronic analgesic experimental studies. Results: The paw edema and formalin fndings showed that the nanogels formulations possess signifcant anti-nociceptive and anti-infammatory efects. Conclusion: The prepared nanogels could be considered as analgesic drugs for inhibiting the infammation and pain of diseases.
Item Type: | Article |
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Keywords: | Analgesics, Nanomedicine, Painkiller, Paw edema test |
Journal or Publication Title: | Bmc Complementary Medicine and Therapies |
Volume: | 22 |
Number: | 1 |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/3739 |
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