(2022) Hybrid PCL/chitosan-PEO nanofibrous scaffolds incorporated with A. euchroma extract for skin tissue engineering application. Carbohydrate Polymers. p. 118926. ISSN 0144-8617
Full text not available from this repository.
Abstract
Skin tissue engineering is an advanced method to repair and regenerate skin injuries. Recent research is focused on the development of scaffolds that are safe, bioactive, and cytocompatible. In this work, a new hybrid nanofibrous scaffold composed of polycaprolactone/chitosan-polyethylene oxide (PCL/Cs-PEO) incorporated with Arnebia euchroma (A. euchroma) extract were synthesized by the two-nozzle electrospinning method. Then the synthesized scaffold was characterized for morphology, sustainability, chemical structure and properties. Moreover, to verify their potential in the burn wound healing process, biodegradation rate, contact angle, swelling properties, water vapor permeability, mechanical properties, antibacterial activity and drug release profile were measured. Furthermore, cytotoxicity and biocompatibility tests were performed on human dermal fibroblasts cell line via XTT and LDH assay. It is shown that the scaffold improved and increased proliferation during in-vitro studies. Thus, results confirm the efficacy and potential of the hybrid nanofibrous scaffold for skin tissue engineering.
Item Type: | Article |
---|---|
Keywords: | Biomaterials; Electrospinning; Hybrid nanofibrous scaffolds; Skin tissue engineering. |
Page Range: | p. 118926 |
Journal or Publication Title: | Carbohydrate Polymers |
Volume: | 278 |
Identification Number: | 10.1016/j.carbpol.2021.118926 |
ISSN: | 0144-8617 |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/3611 |
Actions (login required)
View Item |