(2020) Ameliorative role of metformin on lipopolysaccharide-mediated liver malfunction through suppression of inflammation and oxidative stress in rats. Toxin Reviews. ISSN 15569543
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Abstract
Liver is susceptible to oxidative stress and inflammation. The effect of metformin on lipopolysaccharide (LPS)-mediated liver malfunction was investigated. Rats were grouped into (1) control, (2) LPS, (3–5) LPS as well as 50, 100, and 150 mg/kg of metformin for 5 weeks. LPS increased liver enzymes, IL-6, and malondialdehyde (MDA) (p < 0.05 and p < 0.001) whereas metformin reduced them (p < 0.05 to p < 0.001). LPS decreased total protein, albumin, total thiol, SOD and CAT (p < 0.05 and p < 0.001), and metformin attenuated the effect of LPS (p < 0.05 to p < 0.001). The protective effect of metformin is probably mediated via suppression of inflammation and improvement of oxidative stress status. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Item Type: | Article |
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Keywords: | inflammation; Lipopolysaccharide; liver; oxidative stress |
Journal or Publication Title: | Toxin Reviews |
Journal Index: | ISI, Scopus |
Publisher: | Taylor and Francis Ltd. |
Identification Number: | 10.1080/15569543.2020.1833037 |
ISSN: | 15569543 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/2775 |
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