(2020) PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate. Meta Gene.
![]() |
Text
1-s2.0-S2214540020301031-main.pdf Download (487kB) |
Abstract
PINK1 codes for a serine/threonine-protein kinase located in the mitochondria. This protein contributes in the pathophysiology of both neurodegenerative diseases and cancer. Its transcription has been shown to be regulated by a natural occurring antisense (AS) RNA named PINK1-AS. We examined expression levels of PINK1 and PINK1-AS in 54 breast cancer specimens versus their nearby non-cancerous tissues. We found significant down-regulation of PINK1 in tumoral tissues compared with nearby tissues (P =.003). Yet, expression of PINK1-AS was not remarkably different between tumoral tissues and nearby tissues. Relative expression of PINK1 was associated with mitotic rate (P =.03). We also found trends toward over-expression of PINK1 in younger patient compared with older patients (P =.09) and in grade 2 tumors compared with grade 3 ones (P =.08). The current study delivers further evidences for contribution of PINK1 in the pathophysiology of breast cancer and highlights the context-dependent properties the encoded protein. © 2020 The Authors
Item Type: | Article |
---|---|
Keywords: | PINK1, PINK1-AS, Breast cancer |
Journal or Publication Title: | Meta Gene |
Journal Index: | ISI, Scopus |
Volume: | 25 |
Identification Number: | https://doi.org/10.1016/j.mgene.2020.100748 |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/2203 |
Actions (login required)
![]() |
View Item |