(2014) Orexin (hypocretin): A multi-functional hypothalamic peptide. Koomesh. pp. 275-281. ISSN 16087046
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Abstract
Hypocretins/orexins are novel hypothalamic neuropeptides involved in various hypothalamic mechanisms, such as energy homeostasis and neuroendocrine function. Orexins A (33 amino acids) and B (28 amino acids) are derived from a single pre-pro-orexin polypeptide. Physiological studies over the last ten years have implicated orexin signaling plays a central role in a variety of important biological processes. There is a clear evidence for defects in orexin signaling being involved in obesity and diabetes, narcolepsy, panic anxiety disorder and drug addiction. Therefore, this system may be a potentially important therapeutic target for treatment of sleep disorder, obesity, emotional stress, and addiction. In addtion, it has been well known that orexin-A elicits analgesia. Thus, there is a considerable interest in the drug industry in the development of potent compounds for the manipulation of orexin signaling. Therefore, This a review about recent progress in understanding orexin system.
Item Type: | Article |
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Keywords: | Orexin (hypocretin), Hypothalamic peptide, Reward system, Obesity, Sleep disorder, Addiction |
Page Range: | pp. 275-281 |
Journal or Publication Title: | Koomesh |
Journal Index: | Scopus |
Volume: | 15 |
Number: | 3 |
Publisher: | Semnan University of Medical Sciences |
ISSN: | 16087046 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/198 |
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