(2014) Effect of food deprivation on formalin-induced nociceptive behaviors and beta-endorphin and sex hormones concentration in rats. Iranian Biomedical Journal. pp. 107-113. ISSN 1028852X
|
Text
ibj-18-107.pdf Download (231kB) | Preview |
Abstract
Background: The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. Methods: Food was withdrawn 48 h prior to performing the formalin test, but water continued to be available ad libitum. The formalin was injected into hind plantar paw. Results: There is significant difference between male and female control rats during phase 2B. Following 48-h food deprivation, both male and female rats exhibited enhanced nociceptive behavior in response to formalin. Food deprivation for 12 and 24 h increased and for 48 h decreased beta-endorphin level in male and female rats. Food deprivation for 24 h decreased testosterone level in male, while it had no significant effect on female rats and food deprivation for 48 h decreased testosterone level in both sexes. Food deprivation for 24 h increased estradiol level in female and that for 48 h had no significant effect on male and female rats. Conclusions: The present study demonstrates the existence of food deprivation for 48 h causes enhancement of nociception in the formalin test in male and female rats that has correlation with decrease in plasma beta-endorphin and testosterone levels.
Item Type: | Article |
---|---|
Keywords: | Rat, Food Deprivation, beta-endorphin, Naloxone |
Page Range: | pp. 107-113 |
Journal or Publication Title: | Iranian Biomedical Journal |
Journal Index: | Scopus |
Volume: | 18 |
Number: | 2 |
Identification Number: | 10.6091/ibj.1212.2014 |
ISSN: | 1028852X |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/187 |
Actions (login required)
![]() |
View Item |