Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems

(2019) Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems. Trends in molecular medicine. pp. 1066-1079. ISSN 1471-499X (Electronic) 1471-4914 (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/31703931

Abstract

Spherical nucleic acids (SNAs) are nanostructures consisting of highly oriented, dense layers of oligonucleotides arranged in a spherical 3D geometry. Owing to their unique properties and function, SNAs occupy a material space distinct from 'DNA nanotechnology' and DNA origami. Over the past two decades SNAs have revolutionized gene regulation, drug delivery, gene therapy, and molecular diagnostics, and show promise for both antisense and RNAi therapy. We focus here on recent advances in the synthesis and application of SNAs in gene and drug delivery, diagnostics, and immunomodulation, as well as on the utility of nanoflares as intracellular mRNA detection systems.

Item Type: Article
Keywords: spherical nucleic acids, gold nanoparticles, drug delivery, gene therapy, antisense therapy, immunomodulation
Page Range: pp. 1066-1079
Journal or Publication Title: Trends in molecular medicine
Journal Index: ISI, Pubmed
Volume: 25
Number: 12
Identification Number: https://doi.org/10.1016/j.molmed.2019.08.012
ISSN: 1471-499X (Electronic) 1471-4914 (Linking)
Depositing User: پریسا مرادی
URI: http://eprints.thums.ac.ir/id/eprint/1657

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