(2019) In vitro cytotoxicity assay of D-limonene niosomes: An efficient nano-carrier for enhancing solubility of plant-extracted agents. Research in Pharmaceutical Sciences. pp. 448-458.
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Abstract
The low solubility of the plant-extracted agent like D-limonene in cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded niosomes (D-limonene/Nio) for cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span® 40: Tween® 40: cholesterol (35:35:30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE), and in vitro release behaviour. The obtained niosomes showed a nanometric size and spherical morphology with EE about 87 ± 1.8. Remarkably prolonged release of D-limonene from niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 μM. These results indicated that niosome loaded with phytochemicals can be a promising nano-carrier for cancer therapy applications. © 2019 Medknow Publications. All rights reserved.
Item Type: | Article |
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Keywords: | Cancer therapy; D-limonene; Niosome; Solubility |
Page Range: | pp. 448-458 |
Journal or Publication Title: | Research in Pharmaceutical Sciences |
Journal Index: | Pubmed, Scopus |
Volume: | 14 |
Number: | 5 |
Identification Number: | https://doi.org/10.4103/1735-5362.268206 |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/1549 |
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