Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay

(2019) Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. ISSN 2008-2231 (Electronic) 1560-8115 (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/31134490

Abstract

BACKGROUND: The use of phytochemicals to prevent or suppress tumours is known as chemoprevention. Numerous plant-derived agents have been reported to have anticancer potentials. As one such anticancer phytochemical, diosgenin has several applications which are nevertheless limited due to its low solubility in water. METHODS: We loaded diosgenin into niosome to increase its solubility and hence efficiency. Diosgenin-niosome (diosgenin loaded into niosome) was prepared by thin-film hydration method and characterised by optical microscopy, dynamic light scattering (DLS), scanning electron microscopy (SEM), and UV-visible spectrophotometry. Also, loading efficiency, in vitro drug release, and cytotoxicity assay were performed on HepG2 cell line. RESULTS AND DISCUSSION: Diosgenin-niosome has a nanometric size with a normal size distribution and spherical morphology. The loading efficiency of diosgenin was about 89 with a sustainable and controllable release rate. Finally, the viability of free diosgenin was 61.25, and after loading into niosomes, it was improved to 28.32. CONCLUSION: The results demonstrated that niosomes increase the solubility of naturally derived hydrophobic chemicals and thus enhance their anticancer effect. Graphical abstract.

Item Type: Article
Keywords: Cancer; Diosgenin; Loading efficiency; Niosome; Release rate
Journal or Publication Title: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Journal Index: ISI, Pubmed, Scopus
Identification Number: 10.1007/s40199-019-00277-0
ISSN: 2008-2231 (Electronic) 1560-8115 (Linking)
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/1215

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