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Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

بررسي اثر عصاره هيدروالكلي گياه Sahendica Sahendica بر روی تشنج ناشی از پنتيلن تترازول در موش سوري

(2013) بررسي اثر عصاره هيدروالكلي گياه Sahendica Sahendica بر روی تشنج ناشی از پنتيلن تترازول در موش سوري. Koomesh. pp. 497-504. ISSN 16087046


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Effects of Salvia Sahendica hydroalcoholic extract on PTZinduced seizure in male mice


Introduction: Epilepsy is one of most prevalent disorders of central nervous system that causes sudden convulsions, transient, repetitive and unpredictable seizures. It affects about half to one percent of the world population. Historically, herbs have been used to treat epilepsy. In this study, anti-convulsant effect of Salvia Sahendica extract was investigated in mice. Materials and Methods: Sixty mice were randomly divided into six groups (n=10 in each group). Group one (control group) was received normal saline and another 5 groups were received 150, 300, 600, 900, 1200 mg/kg of the extract. Thirty minute after peritoneal injection of different doses of extract or saline, PTZ (85 mg/kg) were injected and they were immediately transferred to a special cage, and the seizure parameters were evaluated for 30 minutes. Results: The injection of the extract had a dose-dependent effect on prolongation of latency to the onset of clonic and tonic-clonic seizures. The greatest effect was observed at the dose of 600 mg/kg. Tonic-clonic seizures time in the treated animals was also reduced. Additionally, it decreased the rate of mortality and the number of suddenly seizures jumping significantly. Conclusion: The obtained result showed that the extract of Salvia Sahendica has anticonvulsant effects. However, more studies are required to understand its action mechanism and to identify the active components.

Item Type: Article
Keywords: Mice, Pentylenetetrazole, Seizures, Salvia sahendica
Page Range: pp. 497-504
Journal or Publication Title: Koomesh
Journal Index: Scopus
Volume: 14
Number: 4
ISSN: 16087046
Depositing User: دکتر محبوبه عبداللهی

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