Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Effect of Plantago major extract on doxorubicin-induced nephropathy in rat

(2018) Effect of Plantago major extract on doxorubicin-induced nephropathy in rat. Physiology and Pharmacology. pp. 269-278. ISSN 2476-5236

Physiol Pharmacol-v22n4p269-en.pdf

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Official URL: <Go to ISI>://WOS:000458931100007


Introduction: Nephropathy is defined as rational loss of renal function related with glomerulosclerosis and declining glomerular filtration rate. Inflammation and oxidative stress play a critical role in nephropathy. Plantago major has antioxidant effects. The aim of present study is the investigation of the effect of Plantago major hydroalcoholic extract on the oxidative stress and renal function in kidney of rat. Methods: Rats were divided into five groups: control (Co), doxorubicin (DOX), doxorubicin+ vitamin E (DOX+ Vit E), 600mg/kg Plantago major (PM)+ doxorubicin (PM600+ DOX), 1200mg/kg Plantago major (PM)+ doxorubicin (PM1200+ DOX). DOX (5mg/kg, IV), Vit E and PM extract (600 and 1200mg/kg, PO) were administrated for 35 days. Finally, urine, blood samples and renal tissue were collected to measurement of redox markers, functional parameters and renal index percentage. Results: The renal superoxide dismutase (SOD) activity, total thiol and functional parameters significantly reduced and malondialdehyde (MDA) concentration increased in DOX group in comparison with control group. The renal SOD, catalase activities and total thiol content were significantly increased and MDA level decreased in PM treated groups along with DOX group in comparison with DOX group. The functional parameters significantly enhanced in treated groups with PM in comparison with the DOX group. The extract did not relive enhanced renal index induced by DOX. Conclusion: Hydro-alcoholic extracts of PM, specially at its high dose led to an improvement in DOX-induced renal function and oxidative stress.

Item Type: Article
Keywords: Doxorubicin, Plantago major, Oxidative stress, Renal function
Page Range: pp. 269-278
Journal or Publication Title: Physiology and Pharmacology
Journal Index: ISI
Volume: 22
Number: 4
ISSN: 2476-5236
Depositing User: دکتر محبوبه عبداللهی

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