Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Inflammation markers and risk of developing hypertension: a meta-analysis of cohort studies

(2019) Inflammation markers and risk of developing hypertension: a meta-analysis of cohort studies. Heart (British Cardiac Society). ISSN 1468-201X (Electronic) 1355-6037 (Linking)


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OBJECTIVE: To systematically assess the association of circulating inflammation markers with the future risk of hypertension. METHODS: We did a systematic literature search of PubMed and Scopus, from database inception to July 10, 2018. Prospective and retrospective cohort studies evaluating the association of circulating C reactive protein (CRP), high-sensitive CRP (hs-CRP), interleukin 6 (IL-6) and IL-1beta to the risk of developing hypertension in the general population were included. The relative risks (RRs) for the top versus bottom tertiles of circulating biomarkers were calculated using a fixed-effects/random-effects model. A potential non-linear dose-response association was tested. RESULTS: Fourteen prospective cohort studies, two retrospective cohort studies and five nested case-control studies involving 142 640 participants and 20 676 cases were identified. The RR for the third versus first tertiles of circulating CRP was 1.23 (95 CI 1.11 to 1.35; I(2)=59, n=12). The association remained unchanged after adjustment for body mass index. The RRs for other biomarkers were as follows: hs-CRP (RR 1.20, 95 CI 1.02 to 1.37; I(2)=74, n=7), IL-6 (RR 1.51, 95 CI 1.30 to 1.71; I(2)=0, n=5), and IL-1beta (RR 1.22, 95 CI 0.92 to 1.51; I(2)=0, n=3). A non-linear dose-response meta-analysis demonstrated that the risk of hypertension increased linearly with increasing circulating inflammation markers, even within the low-risk and intermediate-risk categories. CONCLUSIONS: Higher levels of circulating CRP, hs-CRP and IL-6, but not IL-1beta, were associated with the risk of developing hypertension. The association persisted in subgroups of studies defined by major sources of heterogeneity.

Item Type: Article
Keywords: hypertension; inflammatory markers; meta-analysis
Journal or Publication Title: Heart (British Cardiac Society)
Journal Index: ISI, Pubmed, Scopus
Identification Number: 10.1136/heartjnl-2018-314216
ISSN: 1468-201X (Electronic) 1355-6037 (Linking)
Depositing User: دکتر محبوبه عبداللهی

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