Abstract

Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Methods: Rats were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of Anethum graveolens L. (i.p. 100, 200 and 400 mg/kg) and Afterdischarge Duration (ADD), Stage 4 latency (S4L) and Stage 5 duration (S5D) were recorded. Results: Hydro-alcoholic extracts of Anethum graveolens L. (200 and 400 mg/kg) significantly increased stage 4 latency compare to the control group (P <0.05). Hydro-alcoholic extracts of Anethum graveolens L. (400 mg/kg) injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of Anethum graveolens L. (100, 200 and 400 mg/kg) injection significantly reduced ADD induced by amygdala kindling. Conclusion: The data showed that injection of hydro-alcoholic extracts of Anethum graveolens L. has anti-epileptic effect and increases the time required for amygdala kindling and may have anticonvulsant effects. © 2018 Institute of Medicinal Plants.All right reserved.