Abstract

Uranium is one of the most critical components in the nuclear field due to its chemical and radiological properties. Since few studies were conducted on uranium concentration in drinking water in Iranian cities, this study aimed to determine the concentration of uranium and flouridein the samples of drinking water collected from tap water in Shiraz, Fars province. Fifty samples were examined for uranium and fluoride presence using the ICP-MS and spectrophotometry methods. Hazard Quotient (HQ) and sensitivity analysis (SA) using the Monte Carlo Simulation technique with 10,000 iterations were applied to determine the human carcinogenic and non-carcinogenic effects of Uranium and Fluoride in three different groups (children, teenagers, and adults). The results showed that uranium and fluoride concentrations varied between 0.18–1.12 μg/L and 0.06–0.56 mg/L, respectively, which is less than the EPA recommendation for both elements. pH, EC, and TDS values were in accordance with the standard, and a positive correlation was observed between fluoride and total dissolved solids (TDS). The highest risk of carcinogenicity was found in the adult group with a value of 3.24E-9, lower than the allowable limit (1E-6). The highest hazard quotient (HQ) for uranium and fluoride was obtained in children with 0.13 and 0.66. Monte Carlo simulation results showed that the hazard quotient (HQ) for both elements in all groups was less than one and consistent with the values of the deterministic method. Also, water swallowing rate and contaminant concentration were the most influential parameters in the sensitivity analysis. © 2022 Informa UK Limited, trading as Taylor & Francis Group.