Abstract

MALAT1 is a long non-coding transcript that affects immune reactions, thus being involved in the pathoaetiology of immune-related conditions. We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95 confidence intervals (CI)) = 0.57 (0.36–0.9)), adjusted p =.02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95 CI) = 0.56 (0.35–0.92), adjusted p =.04) as well as log-additive model (OR (95 CI) = 0.59 (0.38–0.92), adjusted p =.04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population. © 2021 John Wiley & Sons Ltd.