(2021) Protective effect of PPARγ agonist pioglitazone, on testicular tissue and sperm parameters in hypothyroid rats. Toxin Reviews. pp. 267-276. ISSN 15569543 (ISSN)
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Abstract
Both thyroid hormones and PPARγ agonists are suggested to have some effects on the reproductive system. Here, the effects of pioglitazone on testicular tissue damages in propylthiouracil (PTU)-induced hypothyroidism were evaluated. Pioglitazone increased the number of sperm and volume and weight of the testis while, decreased TUNEL positive cells of 0.5 PTU-treated rats. Pioglitazone also improved thiol, superoxide dismutase, and catalase while decreased malondialdehude (MDA) in testicular tissue. Thus, pioglitazone appears to provide a protective effect against on testicular damages induced by PTU. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Keywords: | PPARγ agonist, pioglitazone, testis, hypothyroidism, apoptosis, oxidative stress |
| Page Range: | pp. 267-276 |
| Journal or Publication Title: | Toxin Reviews |
| Volume: | 40 |
| Number: | 3 |
| Identification Number: | 10.1080/15569543.2018.1564775 |
| ISSN: | 15569543 (ISSN) |
| Depositing User: | پریسا مرادی |
| URI: | http://eprints.thums.ac.ir/id/eprint/3520 |
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