(2021) Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats. Naunyn Schmiedebergs Arch Pharmacol. pp. 655-667. ISSN 1432-1912 (Electronic) 0028-1298 (Linking)
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Abstract
The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats. The rats were treated as follows: (1) control, (2) UCMS, (3-5) Vit D 100, 1000, and 10,000 iu + UCMS. Rats were subjected to UCMS for a total of 4 weeks. During week 4, they received seven training trials. The brains were then collected to examine inflammation and oxidative stress criteria. Pretreatment with Vit D enhanced performances of the rats in the elevated plus maze (EPM) and open field (OF) and forced swimming test (FST). UCMS also increased MDA and interleukin-6 (IL-6) levels while decreased CAT, SOD, and thiol. Vit D reversed the effects of UCMS. The results of the current research revealed that Vit D improved UCMS-induced anxiety and depression via decreasing brain oxidative stress and inhibiting neuroinflammation.
| Item Type: | Article |
|---|---|
| Keywords: | Vitamin D, Unpredictable chronic mild stress, Anxiety, Depression, Oxidative stress, Neuroinflammation |
| Page Range: | pp. 655-667 |
| Journal or Publication Title: | Naunyn Schmiedebergs Arch Pharmacol |
| Volume: | 394 |
| Number: | 4 |
| Identification Number: | 10.1007/s00210-020-02002-0 |
| ISSN: | 1432-1912 (Electronic) 0028-1298 (Linking) |
| Depositing User: | دکتر محبوبه عبداللهی |
| URI: | http://eprints.thums.ac.ir/id/eprint/3322 |
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