Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats

(2021) The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. pp. 1-11. ISSN 0300-9831 (Print) 0300-9831 (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/34024144

Abstract

The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162+/-13 U/L), alanine aminotransferase (ALT: 74.6+/-2.15 U/L), alkaline phosphatase (ALK-P: 811+/-51 U/L), interlukine-1beta (IL-1beta: 1254+/-51 pg/g tissue), malondialdehyde (MDA: 32+/-1.09 nM/g tissue), and nitric oxide (NO: 224+/-13.5 nM/g tissue) (P<0.01-P<0.001) while, decreased total protein(4.08+/-0.38 g/dl), albumin(2.79+/-0.16 g/dl), thiol (5.16+/-0.19 muM/g tissue), superoxide dismutase (SOD: 10.57+/-0.13 U/g tissue), and catalase (CAT: 0.78+/-0.02 U/g tissue) compared to control (P<0.001). CAR reversed the effects of LPS (P<0.05-P<0.001). In the rats treated by 100 mg/kg CAR, the indicators were as follows: AST: 118+/-10.1 U/L, ALT: 42.5+/-4.13 U/L, ALK-P: 597+/-39.91 U/L, IL-1beta: 494+/-15 pg/g tissue, and NO: 141+/-5.35 nM/g tissue. Both 50 and 100 mg/kg CAR corrected oxidative stress indicators and in the group treated by 100 mg/kg CAR, they were: MDA: 23.4+/-0.91 nM/g tissue, thiol: 7.98+/-0.18 muM/g tissue, SOD: 21+/-0.8 U/g tissue, and CAT: 1.12+/-0.02 U/g tissue(P<0.05-P<0.001). In conclusion, CAR improved liver function, accompanied with antioxidant and antiinflammatory effects.

Item Type: Article
Keywords: Carvacrol; inflammation; lipopolysaccharide; liver; oxidative stress.
Page Range: pp. 1-11
Journal or Publication Title: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
Identification Number: 10.1024/0300-9831/a000711
ISSN: 0300-9831 (Print) 0300-9831 (Linking)
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/3302

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