(2021) The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. pp. 1-11. ISSN 0300-9831 (Print) 0300-9831 (Linking)
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Abstract
The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162+/-13 U/L), alanine aminotransferase (ALT: 74.6+/-2.15 U/L), alkaline phosphatase (ALK-P: 811+/-51 U/L), interlukine-1beta (IL-1beta: 1254+/-51 pg/g tissue), malondialdehyde (MDA: 32+/-1.09 nM/g tissue), and nitric oxide (NO: 224+/-13.5 nM/g tissue) (P<0.01-P<0.001) while, decreased total protein(4.08+/-0.38 g/dl), albumin(2.79+/-0.16 g/dl), thiol (5.16+/-0.19 muM/g tissue), superoxide dismutase (SOD: 10.57+/-0.13 U/g tissue), and catalase (CAT: 0.78+/-0.02 U/g tissue) compared to control (P<0.001). CAR reversed the effects of LPS (P<0.05-P<0.001). In the rats treated by 100 mg/kg CAR, the indicators were as follows: AST: 118+/-10.1 U/L, ALT: 42.5+/-4.13 U/L, ALK-P: 597+/-39.91 U/L, IL-1beta: 494+/-15 pg/g tissue, and NO: 141+/-5.35 nM/g tissue. Both 50 and 100 mg/kg CAR corrected oxidative stress indicators and in the group treated by 100 mg/kg CAR, they were: MDA: 23.4+/-0.91 nM/g tissue, thiol: 7.98+/-0.18 muM/g tissue, SOD: 21+/-0.8 U/g tissue, and CAT: 1.12+/-0.02 U/g tissue(P<0.05-P<0.001). In conclusion, CAR improved liver function, accompanied with antioxidant and antiinflammatory effects.
Item Type: | Article |
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Keywords: | Carvacrol; inflammation; lipopolysaccharide; liver; oxidative stress. |
Page Range: | pp. 1-11 |
Journal or Publication Title: | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition |
Identification Number: | 10.1024/0300-9831/a000711 |
ISSN: | 0300-9831 (Print) 0300-9831 (Linking) |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/3302 |
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