Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

(2018) Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats. Arquivos de neuro-psiquiatria. pp. 32-40. ISSN 1678-4227 (Electronic) 0004-282X (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29364392

Abstract

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

Item Type: Article
Keywords: hypothyroidism; propylthiouracil; memory
Page Range: pp. 32-40
Journal or Publication Title: Arquivos de neuro-psiquiatria
Journal Index: ISI, Pubmed, Scopus
Volume: 76
Number: 1
Identification Number: 10.1590/0004-282X20170182
ISSN: 1678-4227 (Electronic) 0004-282X (Linking)
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/328

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