(2021) A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats. Biochemistry and Biophysics Reports. ISSN 24055808 (ISSN)
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Abstract
Objective: Inflammation has been considered as an important factor in cardiovascular diseases (CVD). Curcumin has been well known for its anti-inflammatory effects. In current research, protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide (LPS) was investigated in rats. Material and methods: The animals were divided into five groups and received the treatments during two weeks 1: Control in which vehicle was administered instead of curcumin and saline was injected instead of LPS 2, LPS group in which vehicle of curcumin plus LPS (1 mg/kg) was administered 3-5, curcumin groups in them three doses of curcumin (5, 10 and 15 mg/kg) before LPS were administered. Results: Administration of LPS was followed by an inflammation status presented by an increased level of white blood cells (WBC) (p < 0.001). An oxidative stress status was also occurred after LPS injection which was presented by an increased level of malondialdehyde (MDA) while, a decrease in thiols, superoxide dismutase (SOD) and catalase(CAT) in all heart, aorta and serum (p < 0.001). The results also showed that curcumin decreased WBC (doses: 10 and 15 mg/kg) (p < 0.001) accompanying with a decrease in MDA (P < 0.01 and P < 0.001). Curcumin also improved the thiols and the activities of SOD and catalase (P < 0.05, P < 0.01 and P < 0.001). Conclusion: Based on our findings, curcumin can ameliorates oxidative stress and inflammation induced by LPS in rats to protect the cardiovascular system. © 2021
Item Type: | Article |
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Keywords: | Cardiovascular diseases; Curcumin; Inflammation; Lipopolysaccharide; Oxidative stress. |
Journal or Publication Title: | Biochemistry and Biophysics Reports |
Volume: | 25 |
Identification Number: | https://doi.org/10.1016/j.bbrep.2021.100908 |
ISSN: | 24055808 (ISSN) |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/3246 |
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