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Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Pathobiologic Roles of Epstein-Barr Virus-Encoded MicroRNAs in Human Lymphomas

(2018) Pathobiologic Roles of Epstein-Barr Virus-Encoded MicroRNAs in Human Lymphomas. International journal of molecular sciences. ISSN 1422-0067 (Electronic) 1422-0067 (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/29649101

Abstract

Epstein-Barr virus (EBV) is a human gamma-herpesvirus implicated in several human malignancies, including a wide range of lymphomas. Several molecules encoded by EBV in its latent state are believed to be related to EBV-induced lymphomagenesis, among which microRNAs-small RNAs with a posttranscriptional regulating role-are of great importance. The genome of EBV encodes 44 mature microRNAs belonging to two different classes, including BamHI-A rightward transcript (BART) and Bam HI fragment H rightward open reading frame 1 (BHRF1), with different expression levels in different EBV latency types. These microRNAs might contribute to the pathogenetic effects exerted by EBV through targeting self mRNAs and host mRNAs and interfering with several important cellular mechanisms such as immunosurveillance, cell proliferation, and apoptosis. In addition, EBV microRNAs can regulate the surrounding microenvironment of the infected cells through exosomal transportation. Moreover, these small molecules could be potentially used as molecular markers. In this review, we try to present an updated and extensive view of the role of EBV-encoded miRNAs in human lymphomas.

Item Type: Article
Keywords: Epstein–Barr Virus; microRNA; human lymphoma; BamHI-A rightward transcript; BART; Bam HI fragment H rightward open reading frame 1; BHRF1
Journal or Publication Title: International journal of molecular sciences
Journal Index: ISI, Pubmed, Scopus
Volume: 19
Number: 4
Identification Number: 10.3390/ijms19041168
ISSN: 1422-0067 (Electronic) 1422-0067 (Linking)
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/320

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