Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Alteration of the neurogenesis and long term potential of olfactory bulb in an animal model of ptsd

(2020) Alteration of the neurogenesis and long term potential of olfactory bulb in an animal model of ptsd. Acta Neurobiologiae Experimentalis. pp. 344-352. ISSN 00651400 (ISSN)

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Abstract

Failure of extinction of fear-conditioned traumatic memory is the main pathology behind post-traumatic stress disorder (PTSD). Functional and structural dysfunctions in the olfactory system are implicated by studies in PTSD patients. However, little is known regarding the neurobiological networks of trauma-related odor sensitivity in PTSD. Male Wistar rats were exposed with a female cat for 10 min and long-term stress was evaluated by behavioral tests, containing open field (OF) and elevated plus maze (EPM). To prove the PTSD model, the serum level of cortisol was evaluated and compared with the control group. Local field potential (LFP) was applied to compare the electrophysiology of the OB in two groups. To assess neurogenesis, the expression of nestin, and doublecortin were evaluated. Data from EPM revealed a significant increase in spent time in the closed arms in PTSD group. We observed a significant reduction in OF parameters in terms of the total distance traveled, the time spent in the central zone, and the number of crossing the central zone in PTSD group compared to the control group. The mean serum cortisol level was significantly higher in the PTSD group than the control group. In LFP recording, the slope and the amplitude of field excitatory postsynaptic potential (fEPSP) in the PTSD group were significantly higher than that of the control group. Our results also showed that the mRNA expression level of nestin as a neural progenitor marker and doublecortin, as an immature neuron marker, significantly decreased in the PTSD group compared to the control group. This study has shown that PTSD can disrupt the OB function through decreasing neurogenesis. More information on PTSD and OB would help us to establish a greater degree of accuracy on this matter. © 2020byActaNeurobiologiaeExperimentalis.

Item Type: Article
Keywords: Behavioral assessment ,Neurogenesis ,Post-traumatic stress disorder
Page Range: pp. 344-352
Journal or Publication Title: Acta Neurobiologiae Experimentalis
Volume: 80
Number: 4
Identification Number: https://doi.org/10.21307/ane-2020-030
ISSN: 00651400 (ISSN)
Depositing User: پریسا مرادی
URI: http://eprints.thums.ac.ir/id/eprint/3177

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