Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Auraptene has neuroprotective and memory enhancing effects in a rat model of Alzheimer’s disease

(2020) Auraptene has neuroprotective and memory enhancing effects in a rat model of Alzheimer’s disease. Neurology Asia. pp. 353-360. ISSN 18236138

Full text not available from this repository.

Official URL:


Background: Auraptene is a simple coumarin that exhibits multiple protective activities in the brain. Alzheimer’s disease is a complex, multifactorial, and progressive neurodegenerative disease. Microinjection of the β-amyloid peptide (Aβ) into the hippocampus of rat has been recognized as a reliable and stable animal model of Alzheimer’s disease, which mimics the memory deficits. In the present study, the memory enhancing effects of auraptene were studied in rats that Aβ was injected into their hippocampus to create a model of Alzheimer’s disease. Methods: Different doses of auraptene (5, 10 and 25 mg/kg) were administered intraperitoneally to male Wistar rats. The spatial memory performance was tested by Morris water maze after Alzheimer`s induction. The hippocampal expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins were calculated for evaluating the neuroprotective and anti-apoptotic effects of Auraptene in the brain tissue. Results: In comparison with the control group, auraptene significantly decreased the escape latency time in the treated rats. In addition, auraptene increased the percentage of time spent and traveled pathway in the target quadrant. Molecular data showed that auraptene attenuated the Bax/Bcl-2 ratio in the hippocampus of rats. Conclusion: This study demonstrated the memory enhancing effect of Aur after Aβ injection, which could be through inhibiting the apoptotic pathways in the hippocampus of rats. © 2020, ASEAN Neurological Association. All rights reserved.

Item Type: Article
Keywords: Auraptene; Bax protein; Rat/Wistar; Spatial memory
Page Range: pp. 353-360
Journal or Publication Title: Neurology Asia
Journal Index: Scopus
Volume: 25
Number: 3
Publisher: ASEAN Neurological Association
ISSN: 18236138
Depositing User: دکتر محبوبه عبداللهی

Actions (login required)

View Item View Item