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Torbat Heydariyeh University of Medical Sciences

Effects of supplementation with quercetin on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials

(2017) Effects of supplementation with quercetin on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition. pp. 1033-1039. ISSN 09543007

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Abstract

Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations. A systematic search was performed in several databases including SCOPUS, PubMed-Medline and Google Scholar until 16 June 2016. We used a random-effects model in combination with weight mean difference (WMD) and 95 confidence intervals (CI) for data analysis. Standard methods were used for the assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias. The meta-analysis of seven RCTs (10 treatment arms) showed a significant reduction of circulating CRP levels (WMD: -0.33 mg/l; 95 CI: -0.50 to -0.15; P<0.001) following quercetin supplementation. In the subgroup analysis, a significant reducing effect was observed in trials with �500 mg/day dosage (WMD: -0.34 mg/l; 95 CI: -0.52, -0.16; P�0.001) and in those with CRP <3 mg/l (WMD: -0.34 mg/l; 95 CI: -0.51, -0.18; P�0.001). In meta-regression, there was no association between changes in CRP concentrations, dose of supplementation and CRP baseline values. Our findings showed a significant effect of quercetin supplementation on the C-reactive protein - especially at doses above 500 mg/day and in patients with CRP <3 mg/l. © The Author(s) 2017.

Item Type: Article
Keywords: -
Page Range: pp. 1033-1039
Journal or Publication Title: European Journal of Clinical Nutrition
Journal Index: ISI, Pubmed, Scopus
Volume: 71
Number: 9
Publisher: Nature Publishing Group
Identification Number: 10.1038/ejcn.2017.55
ISSN: 09543007
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/248

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