Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Immunoregulatory Effects of Krocina, a Herbal Medicine Made of Crocin, on Osteoarthritis Patients: A Successful Clinical Trial in Iran

(2020) Immunoregulatory Effects of Krocina, a Herbal Medicine Made of Crocin, on Osteoarthritis Patients: A Successful Clinical Trial in Iran. Iranian journal of allergy, asthma, and immunology. pp. 253-263. ISSN 1735-5249 (Electronic) 1735-1502 (Linking)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/32615659

Abstract

Osteoarthritis (OA) is the major cause of joint pain and disability. This research was planned to examine the effects of Krocina, aherbal medicine made of crocin, an ingredient of saffron, in patients with OA. Forty patients suffering from OA were enrolled in our study and randomly divided into two groups, receiving Krocina and placebo, and the clinical trial continued for four months.Peripheral blood was taken from all patients and the percentage ofvarious subsets of T cells in addition to the levels of forkhead box protein P3 (FOXP3) and interleukin (IL)-17 were measured by flow cytometry technique. The visualan alog scale (VAS) index analysis decreased significantly in both groups (krocinaTM and placebo) (p<0.05). Assessment of the C-reactive protein (CRP) level in serum showed a significant decrease in the krocinaTM group (p<0.05). Moreover, we found a meaningful increase in the percentage of regulatory T cells (Tregs)cellin samples gathered from Krocina group (P=0.02) patients. The mean percentages of T helper (Th) 17 cellsinthe Krocina group and CD8+ T cellsin the placebo group patients were also meaningfully reduced (p<0.05). The geometric mean fluorescence intensity (GMFI) for IL-17 showed a significant decrease and increase in Krocina and placebo groups, respectively (p<0.05). No noticeable difference was observed in the percentages of Th cells and GMFI-FOXP3 in either group. Treg/Th17 ratio was shifted towards Tregscell in Krocina group at the end of the intervention. It is concluded that Krocina has immunoregulatory effects on patients with OA, ameliorating the disease.

Item Type: Article
Keywords: ,Clinical trial, Crocin, Immune regulation, Inflammation Osteoarthritis, T helper cells
Page Range: pp. 253-263
Journal or Publication Title: Iranian journal of allergy, asthma, and immunology
Journal Index: Pubmed
Volume: 19
Number: 3
Identification Number: 10.18502/ijaai.v19i3.3453
ISSN: 1735-5249 (Electronic) 1735-1502 (Linking)
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/2308

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