Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Prevalence and phylogenetic analysis of HTLV-1 in a segregated population in Iran

(2016) Prevalence and phylogenetic analysis of HTLV-1 in a segregated population in Iran. Journal of Medical Virology. pp. 1247-1253. ISSN 01466615

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Human T-lymphotropic virus type 1 (HTLV-1) infection is an important health issue that affects a variety of endemic areas. The Khorasan province, mainly its capital Mashhad in northeastern Iran, was reported to be as one of these endemic regions. Torbat-e Heydarieh, a large city Southwest border to Mashhad with a segregated population was investigated for the prevalence and associated risk factors of HTLV-1 infection in 400 randomly selected individuals. Blood samples were tested for the presence of HTLV-1 antibodies via the ELISA method and then were confirmed by an Immunoblot test. For the presence of HTLV-1 in lymphocytes of infected subjects, PCR was performed on LTR and TAX regions. DNA sequencing of LTR fragment was also carried out to determine the phylogenetic of HTLV-1, using the Maximum likelihood method. HTLV-1 sero-reactivity (sero-prevalence) among the study population was 2 (8/400), of which 1.25 had HTLV-1 provirus in lymphocytes (actual prevalence). HTLV-1 infection was significantly associated with the age, marital status, and history of blood transfusion (P<0.05). However, there were no statistical differences between HTLV-1 infection, and gender, surgery, and hospitalization. In regression analysis, age showed the most significant correlation with the infection (P=0.006, OR=4.33). Based on our phylogenetic study, the HTLV-1 prevalent sequence type of Torbat-e Heydarieh belongs to the cosmopolitan subtype A. HTLV-1 prevalence in Torbat-e Heydarieh (1.25) is low comparing to those of both Mashhad (2-3) and Neishabour (3.5-5) in the province of Khorasan. Thus, traveling mobility and population mixing such as marriage, bureaucratic affairs, occupation, and economic activities could be the usual routs of HTLV-1 new wave of spreading in this segregated city. J. Med. Virol. 88:1247-1253, 2016. © 2015 Wiley Periodicals, Inc.

Item Type: Article
Keywords: Iran; epidemiology; human T-cell leukemia virus type 1 (HTLV-1); human T-cell leukemia virus type 2 (HTLV-2)
Page Range: pp. 1247-1253
Journal or Publication Title: Journal of Medical Virology
Journal Index: Scopus
Volume: 88
Number: 7
Publisher: John Wiley and Sons Inc.
Identification Number: 10.1002/jmv.24448
ISSN: 01466615
Depositing User: دکتر محبوبه عبداللهی

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