(2020) The effect of captopril on inflammation-induced liver injury in male rats. Toxin Reviews. pp. 275-283.
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Abstract
Activation of macrophages-induced by lipopolysaccharide (LPS) is accompanied by the production of reactive oxygen species and inflammatory cytokines to induce hepatic injury. Renin–angiotensin system may play a role in liver damage. In the current study, the effect of captopril on the injury of inflammation-induced liver was investigated. The rats were divided into (1) Control, (2) LPS, and (3–5) LPS as well as 10, 50, or 100 mg/kg captopril for 2 weeks. Captopril decreased NO metabolites, IL-6, and MDA, while it increased CAT, SOD, and total thiol in the liver. Captopril also attenuated AST, ALT, and ALK-P, whereas it increased albumin and total protein in serum. As an ACE inhibitor, captopril improved liver function and attenuated inflammation and oxidative stress induced by LPS injection. © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Item Type: | Article |
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Keywords: | captopril; inflammation; Lipopolysaccharide; liver; oxidative stress |
Page Range: | pp. 275-283 |
Journal or Publication Title: | Toxin Reviews |
Journal Index: | ISI, Scopus |
Volume: | 39 |
Number: | 3 |
Identification Number: | 10.1080/15569543.2018.1517802 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/2211 |
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