(2015) Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome. Iranian Journal of Reproductive Medicine. pp. 373-378. ISSN 16806433
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Abstract
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples. Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS. © 2015, Research and Clinical Center for Infertitlity. All rights reserved.
Item Type: | Article |
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Keywords: | Polycystic ovary syndrome, Infertility, CRP, Antioxidant, AOPP |
Page Range: | pp. 373-378 |
Journal or Publication Title: | Iranian Journal of Reproductive Medicine |
Journal Index: | ISI, Pubmed, Scopus |
Volume: | 13 |
Number: | 6 |
Publisher: | Research and Clinical Center for Infertitlity |
ISSN: | 16806433 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/213 |
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