Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Curcumin modulates long term potentiation in lipopolysaccharide-treated rats

(2020) Curcumin modulates long term potentiation in lipopolysaccharide-treated rats. PharmaNutrition.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Curcumin is a component of turmeric isolated from the rhizome of Curcuma longa. Natural polyphenols like curcumin have long been used to heal several pathological states. This study aimed to evaluate the effects of curcumin on lipopolysaccharide (LPS)-induced modifications of long-term potentiation (LTP) in rats. Five groups of rats with seven in each were allocated to the experimental groups. The experimental groups were defined as: (1) control, (2) LPS (1 mg/kg), (3) LPS-Cur 5 mg/kg, (4) LPSCur 10 mg/kg, and (5) LPS-Cur 15 mg/kg. Afterward, LTP was recorded from the CA1 region of the hippocampus following high-frequency stimulus application to the Schaffer collateral. Our results indicated that the amplitude and slope components of the field excitatory post-synaptic potential (fEPSP) were reduced after the LPS administration in the control animals. Treatment by the high dose of curcumin (15 mg/kg) restored these parameters in comparison with the LPS-treated group. This investigation suggested that curcumin at a high dose could recover LTP impairments induced by LPS in adult male rats. © 2020 Elsevier B.V.

Item Type: Article
Keywords: Curcumin; Lipopolysaccharide; Long term potentiation; Neurodegenerative disorder
Journal or Publication Title: PharmaNutrition
Journal Index: Scopus
Volume: 13
Identification Number: 10.1016/j.phanu.2020.100195
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/1994

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