(2014) Effects of hydroalcoholic extract of tanacetum sonbolii (Asteraceae) on pain-related behaviors during formalin test in mice. Basic and Clinical Neuroscience. pp. 162-168. ISSN 2008126X
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Abstract
Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. Methods: 126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups; n = 6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/ kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group. Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.
Item Type: | Article |
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Keywords: | Tanacetum Sonbolii; Morphine ; Formalin Test, Mice |
Page Range: | pp. 162-168 |
Journal or Publication Title: | Basic and Clinical Neuroscience |
Journal Index: | Pubmed, Scopus |
Volume: | 5 |
Number: | 2 |
Publisher: | Iran University of Medical Sciences |
ISSN: | 2008126X |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/199 |
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