(2014) Role of orexin in the tolerance and physical dependence to morphine. Journal of Babol University of Medical Sciences. pp. 54-61. ISSN 15614107
|
Text
Babol-Jbums-v16n12p54-en.pdf Download (211kB) | Preview |
Abstract
BACKGROUND AND OBJECTIVE: Although opioid drugs cause analgesia and more effective in treatment of pain but, its utility is hindered by the development of tolerance to its analgesic effects. Orexin A and B (hypocretin 1 and 2) discovered in 1998 and projected to large areas of the brain regions involved in the tolerance and dependence to morphine. The attenuated withdrawal syndrome seen in orexinknock-out mice suggests that such regulation of orexin neurons may be an important contributor to morphine physical dependence and to the expression of withdrawal. METHODS: This systematic review conducted on articles published on orexin from 1998 to 2012 in the following electronic databases: Medline, Pubmed, ISI and Scopus by using keywords including morphine, orexin, tolerance and dependence. FINDINGS: Although morphine-tolerance tended to develop in response to repeated injections of morphine, pre-treatment of OXR1 antagonist prevented this effect, causing a delay in the development of morphine-tolerance. Moreover, co-administration of orexin receptor 1 antagonist with morphine significantly decreased the somatic signs of withdrawal. CONCLUSION:This suggested development of orexin receptor antagonists could prevent the development of tolerance and dependence to morphine. © 2014 Babol University of Medical Sciences. All rights reserved.
Item Type: | Article |
---|---|
Keywords: | Morphine, Orexin, Tolerance, dependence |
Page Range: | pp. 54-61 |
Journal or Publication Title: | Journal of Babol University of Medical Sciences |
Journal Index: | Scopus |
Volume: | 16 |
Number: | 12 |
Publisher: | Babol University of Medical Sciences |
ISSN: | 15614107 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/192 |
Actions (login required)
![]() |
View Item |