(2013) اثر غیر فعال کردن مًقتی بخش ريسترال شکمی- میاوی بصل النخاع روی بی دردی ناشی از استرس شنا در آزمون فرمالیه در موش صحرایی. Physiology and Pharmacology. pp. 116-124. ISSN 17350581
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Title
Effect of transient inactivation of rostral ventromedial medulla on swim stressinduced analgesia in formalin test in rats
Abstract
Introduction: Despite significant progress in understanding pain control mechanism, there are numerous questions about central nervous mechanisms underlying stress-induced analgesia. The rostral ventromedial medulla (RVM) in the brainstem integrates a variety of functions, including pain modulation and pain perception. In the present study, we investigated the effect of temporary inactivation of RVM on stress-induced analgesia. Methods: This study was performed using adult male Wistar rats (200-250 gr). Swim stress was induced using a cylinder filled with water (50 cm height, 20±1°C) in which the rats were kept for 3 min. For induction of pain, 50 μL of 2 formalin was injected subcutaneously in the hind paw. For temporary inactivation of RVM, 0.5 μL of 2 lidocaine was injected into RVM. Results: Injection of lidocaine into RVM, before inducing swim stress, potentiated the anti-nociceptive effects of swim stress in phase 1 and phase 2A. In phase 2B swim stresses increased nociceptive scores of formalin test; so administration of lidocaine into RVM inhibited the effect of swim stress. Conclusion: The result of this study demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced analgesia.
Item Type: | Article |
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Keywords: | Rostral Ventromedial Medulla, Lidocaine, Formalin test, Stress-induced analgesia |
Page Range: | pp. 116-124 |
Journal or Publication Title: | Physiology and Pharmacology |
Journal Index: | Scopus |
Volume: | 17 |
Number: | 1 |
ISSN: | 17350581 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/186 |
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