(2020) Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo. Materials Science and Engineering C.
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Abstract
In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Cerium oxide nanoparticle showed potential anti-cancer properties against fibrosarcoma. © 2019 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Keywords: | Cerium oxide nanoparticles, Fibrosarcoma, TUNEL, Bax, Bcl2 |
| Journal or Publication Title: | Materials Science and Engineering C |
| Journal Index: | ISI, Pubmed, Scopus |
| Volume: | 109 |
| Identification Number: | 10.1016/j.msec.2019.110533 |
| Depositing User: | دکتر محبوبه عبداللهی |
| URI: | http://eprints.thums.ac.ir/id/eprint/1855 |
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