(2019) Modulation of microRNAs by aspirin in cardiovascular disease. Trends in cardiovascular medicine. ISSN 1873-2615 (Electronic) 1050-1738 (Linking)
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Abstract
Aspirin is among the most widely prescribed drugs in cardiovascular and cerebrovascular diseases for both primary and secondary prevention. The major mechanisms underlying its benefits are the inhibitory effects on platelet activation and prostanoid biosynthesis induced by COX-1 and COX-2 inactivation. MicroRNAs (miRNAs) are newly proposed mediators of the effects of aspirin. In this review, we summarize the evidence on the links between miRNAs and aspirin use in relation to cardiovascular diseases. In addition, we discuss the studies suggesting a possible role for miRNAs as biomarkers of aspirin resistance, a condition during which atherothrombotic events occur despite aspirin use, and which affects a considerable proportion of patients with cardiovascular disease.
Item Type: | Article |
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Keywords: | Aspirin, Aspirin resistance, Cardiovascular disease, MicroRNA Thrombosis |
Journal or Publication Title: | Trends in cardiovascular medicine |
Journal Index: | ISI, Pubmed, Scopus |
Identification Number: | https://doi.org/10.1016/j.tcm.2019.08.005 |
ISSN: | 1873-2615 (Electronic) 1050-1738 (Linking) |
Depositing User: | پریسا مرادی |
URI: | http://eprints.thums.ac.ir/id/eprint/1679 |
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