Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

In vitro cytotoxicity assay of D-limonene niosomes: An efficient nano-carrier for enhancing solubility of plant-extracted agents

(2019) In vitro cytotoxicity assay of D-limonene niosomes: An efficient nano-carrier for enhancing solubility of plant-extracted agents. Research in Pharmaceutical Sciences. pp. 448-458.

[img] Text
JResPharSciDrHajizadeMalekiDilimonen2019.pdf

Download (796kB)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The low solubility of the plant-extracted agent like D-limonene in cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded niosomes (D-limonene/Nio) for cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span® 40: Tween® 40: cholesterol (35:35:30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE), and in vitro release behaviour. The obtained niosomes showed a nanometric size and spherical morphology with EE about 87 ± 1.8. Remarkably prolonged release of D-limonene from niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 μM. These results indicated that niosome loaded with phytochemicals can be a promising nano-carrier for cancer therapy applications. © 2019 Medknow Publications. All rights reserved.

Item Type: Article
Keywords: Cancer therapy; D-limonene; Niosome; Solubility
Page Range: pp. 448-458
Journal or Publication Title: Research in Pharmaceutical Sciences
Journal Index: Pubmed, Scopus
Volume: 14
Number: 5
Identification Number: 10.4103/1735-5362.268206
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/1549

Actions (login required)

View Item View Item