(2019) Effects of blood pressure-lowering drugs in heart failure: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. pp. 1757-1767. ISSN 1473-5598 (Electronic) 0263-6352 (Linking)
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Abstract
: We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure (BP)-lowering properties to assess the extent to which such drugs reduce BP in heart failure, the association between the net change in BP between treatment arms and cause-specific outcomes and whether treatment effects (efficacy and safety) vary according to baseline BP. We conducted a systematic review and meta-analysis including randomized clinical trials of drugs with BP-lowering properties in patients with chronic heart failure with at least 300 patient-years follow-up. We included a total of 37 trials (91 950 patients) and showed that treatment with drugs with BP-lowering properties resulted in a small but significant decrease in SBP in patients with heart failure with no evidence that the efficacy and safety of those drugs varied according to baseline BP.
Item Type: | Article |
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Keywords: | - |
Page Range: | pp. 1757-1767 |
Journal or Publication Title: | J Hypertens |
Journal Index: | Pubmed, Scopus |
Volume: | 37 |
Number: | 9 |
Identification Number: | 10.1097/HJH.0000000000002094 |
ISSN: | 1473-5598 (Electronic) 0263-6352 (Linking) |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/1347 |
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