(2019) Investigating micronucleus changes in mouse lymphocytes due to exposure to silica dust. Open Biomarkers Journal. pp. 17-21. ISSN 18753183
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Abstract
Background and Objectives: Occupational exposure to silica dust has multiple consequences, including genetic complications. One of the genetic complications is Micronucleus (MN) changes; therefore, this study aims to evaluate the rate of MN formation in mouse lymphocyte cells due to exposure to silica dust. Materials and Methods: Totally 72 male mice BALB/c were selected and categorized into five exposure groups with 12 mice in exposure to the concentrations of 1.3, 3, 8, 12, and 17 mg/m 3 of 99 pure silica dust and a control group. The mice were exposed to silica dust in which they were exposed for 8 hours a day, 6 days a week, and for 1, 2, 3, and 4 months. Then, blood samples were taken from the mice and the rate of MN formation in their lymphocyte cells was evaluated. The results were analyzed via SPSS software version 21 (P<0.05). Results: Maximum and minimum averages of dust concentration, related to boxes 1 and 5, were 17 mg/m 3 and 1.3 mg/m 3 , respectively. Maximum rate of MN formation was observed in the fourth month of exposure and in group 1 with the value of 21.6±1.15, and minimum rate of MN formation was observed in the third month of exposure and in control group with the value of 3±1. Average of MN frequencies in each of the exposure month was significant related to the control group (P=0.001). There was a direct and significant correlation between exposure concentrations of exposed group and average rate of MN formation (r=0.679). Conclusions: More than 3 months exposure to silica dust may lead to significant MN formation in lymphocytes of mice BALB/c in comparison with the control group. © 2019 Golbabaei et al.
Item Type: | Article |
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Keywords: | BALB/c; Dust concentration; Lymphocytes; Micronucleus; Mouse; Silica dust |
Page Range: | pp. 17-21 |
Journal or Publication Title: | Open Biomarkers Journal |
Journal Index: | Scopus |
Volume: | 9 |
Number: | 1 |
Publisher: | Bentham Science Publishers B.V. |
Identification Number: | 10.2174/1875318301909010017 |
ISSN: | 18753183 |
Depositing User: | دکتر محبوبه عبداللهی |
URI: | http://eprints.thums.ac.ir/id/eprint/1201 |
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