(2019) Protective effect of PPARγ agonist pioglitazone, on testicular tissue and sperm parameters in hypothyroid rats. Toxin Reviews. ISSN 15569543
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Abstract
Both thyroid hormones and PPARγ agonists are suggested to have some effects on the reproductive system. Here, the effects of pioglitazone on testicular tissue damages in propylthiouracil (PTU)-induced hypothyroidism were evaluated. Pioglitazone increased the number of sperm and volume and weight of the testis while, decreased TUNEL positive cells of 0.5 PTU-treated rats. Pioglitazone also improved thiol, superoxide dismutase, and catalase while decreased malondialdehude (MDA) in testicular tissue. Thus, pioglitazone appears to provide a protective effect against on testicular damages induced by PTU. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Keywords: | apoptosis; hypothyroidism; oxidative stress; pioglitazone; PPARγ agonist; testis |
| Journal or Publication Title: | Toxin Reviews |
| Journal Index: | Scopus |
| Publisher: | Taylor and Francis Ltd |
| Identification Number: | 10.1080/15569543.2018.1564775 |
| ISSN: | 15569543 |
| Depositing User: | دکتر محبوبه عبداللهی |
| URI: | http://eprints.thums.ac.ir/id/eprint/1190 |
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