Repository of Research and Investigative Information

Repository of Research and Investigative Information

Torbat Heydariyeh University of Medical Sciences

Therapeutic potential of toll-like receptors in treatment of gynecological cancers

(2019) Therapeutic potential of toll-like receptors in treatment of gynecological cancers. IUBMB Life. pp. 549-564. ISSN 15216543

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Toll-like receptors (TLRs) play an important role in the innate and adaptive immune system. They are expressed in various regions of the female reproductive tract, and their regulation may be involved in the pathogenesis of gynecological lesions. There is growing evidence that ligands for several TLRs are potentially anticancer agents, some of which have already been approved by the FDA, and these compounds are now undergoing clinical evaluation. There is a rationale for using these ligands as adjuvants in the treatment or prevention of gynecological cancer. Some TLR agonists that are of potential interest in the treatment of gynecological lesions include imiquimod, motolimod, cervarix, and CpG-oligodeoxynucleotides (ODNs). In this review, we outline the different functions of TLRs in gynecological cancer with particular emphasis on the value of TLR agonists as a potential therapeutic target in the treatment of gynecological cancer. © 2019 IUBMB Life, 71(5):549564, 2019. © 2019 International Union of Biochemistry and Molecular Biology

Item Type: Article
Keywords: anticancer agents; gynecological cancer; toll-like receptors
Page Range: pp. 549-564
Journal or Publication Title: IUBMB Life
Journal Index: Scopus
Volume: 71
Number: 5
Publisher: Blackwell Publishing Ltd
Identification Number: 10.1002/iub.2011
ISSN: 15216543
Depositing User: دکتر محبوبه عبداللهی
URI: http://eprints.thums.ac.ir/id/eprint/1165

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