Abstract

Introduction: The most common form of dementia, which is the progressive loss of cognitive function and often occurs in old age, is Alzheimer's disease. Alzheimer's disease is a chronic progressive and debilitating brain disorder that has had profound effects on memory, intelligence and self-care. Considering that in some studies there was no significant relationship between Alzheimer's disease and diabetes. Therefore, this epidemiological study was conducted to investigate patients with Alzheimer's and some of its risk factors with the aim of determining the Epidemiological and clinical study of patients with Alzheimer's in Five Cities of Khuzestan Province in 2016-2018. Materials and methods: The study included 854 patients with Alzheimer's cases that were inhabited by five of the Khuzestan Province, and reviewing patient records was performed by ten researchers. After obtaining the necessary permissions and sponsorship by Behbahan University of medical sciences, Patients were informed through written consent; their files were used for this study. The data in this study included demographic, laboratory and clinical data of patients. Data were entered into SPSS software version 18 and analyzed by descriptive statistics, analytical tests and significant level of P < 0.05. Results: The study included 854 Alzheimer's patients with a mean age of 63.00 +/- 11.51 years. Of these, 66.8 were male and the rest were women. In this study, 230 (26.9) patients had a history of smoking and did not consume the rest. Of the 225 (26.3) patients with Alzheimer's family history, 144 (34.8) had a history of diabetes. Also, 25.5 of the family history of diabetes, 99 (11.5) had a history of mental illness. There was a significant relationship between marital status and diabetes history (p < 0.0001). There was a significant relationship between marital status and smoking history (p = 0.003). Conclusion: In this study, there was a significant relationship between the history of smoking and Alzheimer's history, and also was significant relationship between the history of diabetes and the history of Alzheimer's disease, So it can be said that diabetes and smoking are two risk factors for Alzheimer's disease. It is necessary to identify other important risk factors by conducting epidemiological studies such as the current study and even the larger sample size. It is also better to take the necessary measures to prevent the risk of a new factor for the disease.